http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1272466-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e83d93ed02bbd6159e99b5a7796e3686 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C327-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-363 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C327-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-363 |
| filingDate | 2001-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e1e97a7bea002bc211635fefa8bba34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3fbae0df01f5313bb7519a688b92bf14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1521a8fe2bf0f1d8675a5080461ff230 |
| publicationDate | 2003-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1272466-A1 |
| titleOfInvention | Method for the preparation of (s)-2-acetylthio-3-phenylpropionic acid |
| abstract | Method for the preparation of (S)-2-acetylthio-3-phenylpropionic acid, wherein (R)-2-bromo-3-phenylpropionic acid is contacted with thioacetic acid and an organic base, for example triethylamine. Preferably the base is metered to a mixture of (R)-2-bromo-3-phenylpropionic acid and thioacetic acid at a temperature between -10 °C and +30 °C. (R)-2-bromo-3-phenylpropionic acid is preferably prepared starting from D-phenylalanine, sodium nitrite, HBr and a bromide salt, in an aqueous solution at a temperature between -10 and 30 °C, and subsequently without isolation converted into (S)-2-acetylthio-3-phenylpropionic acid. The (S)-2-acetylthio-3-phenylpropionic acid obtained can be used in the preparation of pharmaceuticals, in particular ACE inhibitor such as Omapatrilat. |
| priorityDate | 2000-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.