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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-065
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-34
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-06
filingDate 2001-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2004-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c359aaf700abad6794ca7e9068409409
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_044d4a3e7742ccb3eadae48870cf02e4
publicationDate 2004-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1268551-B1
titleOfInvention A METHOD OF PRODUCING IgG
abstract A method for producing IgG from plasma for medical applications, comprising at least: (i') removal of albumin resulting in an IgG fraction, (ii') purifying IgG from an IgG fraction, which is derived from the IgG fraction obtained in step (i'), by adsorbing IgG to a cation exchanger and collecting the adsorbed IgG fraction, and (iii') virus inactivation in an IgG fraction derived from the IgG fraction collected in step (ii'). The method is characterized in; (I) concentrating the IgG fraction obtained in step (i'), (II) adjusting pH to 4±0.1 in the IgG fraction released from the cation exchanger in step (ii'), and preferably maintaining the pH below 6.0 during the remaining steps of the method; and (III) carrying out the virus inactivation (step iii') by using chemicals at a temperature of 30° C.±2° C. for at least 4 hours. Anticomplementary activity is typically below 1 CH50/mg immunoglobulin.
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