| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1542e8802a0e6a7a8a7c6bd5627eb857 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 |
| filingDate |
2001-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2006-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21fcecf2952e453d3bc538907ad1ae02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_330f7ab89cd8c351a84784d35b628a34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f36238da1726661257acf1dc6d5671f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5493b13fa84fd386698bf481046a0bfe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5480b6ee6d3f20a74d141783f1bbc1d2 |
| publicationDate |
2006-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1268545-B1 |
| titleOfInvention |
Potassium channel protein kcnq5, a target for diseases of central nervous system and cardiovascular system |
| abstract |
A DNA sequence (I) encoding: (i) a polypeptide (II) with KCNQ5 activity; (ii) a polypeptide with the amino acid (aa) sequence of KCNQ5; (iii) a fully defined sequence (S2) of 932 aa as given in the specification; or (iv) derivatives of S2 with one or more aa deletions or exchanges, is new. Independent claims are also included for the following: (1) proteins encoded by (I); (2) host cells containing at least one (I); and (3) screening assay for identifying compounds (A) that modulate the activity of (II). - ACTIVITY : Neurological; cardiovascular; anticonvulsant. - MECHANISM OF ACTION : Modulation of the voltage-dependent KCNQ5 potassium channel, a key regulator of membrane potential and modulator of excitability of electrically activated cells such as neurons and cardiomyocytes. KCNQ5 may be implicated in some forms of epilepsy. |
| priorityDate |
2000-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |