abstract |
An improved process for preparing fluromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether (sevoflurane) by reacting 1,1,1,3,3,3-hexafluoro-2-propanol with formaldhyde and hydrogen fluoride either A) under distillation conditions or B) in the presence of or with the subsequent addition of a solvent capable of selectively extracting sevoflurane. |