http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1267760-A2

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filingDate 2001-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_615da3ea96649a8ea4e4d8fc1ff29a06
publicationDate 2003-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1267760-A2
titleOfInvention Medical procedure
abstract The use of an intravascular cooling element to induce hypothermia in connection with a medical procedure. According to a first aspect of the present invention, a coronary bypass procedure is conducted in which a patient's blood is oxygenated with the patient's lungs and in which blood is circulated using the patient's heart or using an intracorporeal pump. The procedure preferably comprises: (a) positioning a heat transfer element in a blood vessel of a patient; (b) cooling the body of the patient to less than 35 DEG C, more preferably 32+/-2 DEG C, using the heat transfer element; and (c) forming a fluid communicating graft between an arterial blood supply and the coronary artery. The body of the patient is preferably heated to about 37 DEG C using the heat transfer element subsequent to the step of forming the fluid communicating graft. According to a further aspect of the invention, a hypothermic medical procedure is provided while a patient is in a conscious or semiconscious state, comprising (a) administering a beta-blocking drug to the patient; b) delivering a heat transfer element to a blood vessel of the patient; and c) cooling a region of the patient or the body of the patient to less than 35 DEG C using the heat transfer element. According to yet a further aspect of the invention, a method is provided which comprises: (a) inducing hypothermia in a human patient in need of neural protection due to ischemic neural conditions, the step of inducing hypothermia comprising (i) positioning a heat transfer element in a blood vessel of a patient and (ii) cooling the body of the patient or a region of the body of the patient to less than 35 DEG C using the heat transfer element; and (b) administering to the patient a therapeutic agent selected from (i) a free-radical scavenger, (ii) an N-methyl-D-aspartame receptor antagonist and (iii) an antipyretic agent, the therapeutic agent being provided in an amount effective to supplement neural protection provided by the step of inducing hypothermia.
priorityDate 2000-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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