http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1267162-A4

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filingDate 2001-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_436695d5543c3eb38e7f83c85c6a54c1
publicationDate 2007-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1267162-A4
titleOfInvention EASY PROCESS FOR BIOLOGICAL EVALUATION OF NATURAL AND ARTIFICIAL CHEMICALS BY USING A DNA INJURY INDEX AND DEVICE THEREFOR
abstract A biological evaluation method for rationally and simply evaluating biological harmfulness or efficacy of a great number of natural and artificial chemicals, foods, etc. This method comprises adding a known amount of 2'-deoxyguanosine (dG) to a solution containing a test substance (drug, pesticide, functional food, etc.), optionally irradiating with UV light and/or adding an active oxygen generator, then quantifying 8-hydroxy-2'-deoxyguanosine (8OHdG) in the above solution, and evaluating the toxicity or efficacy of the above test substance depending on the 8OHdG content (a higher 8OHdG content indicates a higher harmfulness of the test substance while a lower 8OHdG content indicates a lower harmfulness or an efficacy thereof). An apparatus for advantageously carrying out the above biological evaluation method and an antioxidant preservative solution to be used in this apparatus are provided.
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