http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1266898-A4
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5929f2d6f4dba84be8dd3a8ba633db12 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-38 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-38 |
| filingDate | 2001-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed70aba4a5dc18552727935a769ecb56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9281d3c93aad6721fa2db97f4859031 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6dce3336aa3fb8614b220646c96e0516 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e52d0811831b93c686cb4961ddfcf2cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6737819d559ddbf9b9315801615f2c2 |
| publicationDate | 2003-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1266898-A4 |
| titleOfInvention | PROCESSES FOR PRODUCING THIENOPYRAMIDINE DERIVATIVES |
| abstract | Processes for mass-producing on an industrial scale intermediates for the preparation of thienopyrimidine derivatives exhibiting GnRH antagonism, and so on. Specifically, a process for the production of compounds of the general formula (III) or salts thereof (wherein R1 is hydrogen, nitro, halogeno, phthalimido, mono- or di-(alkylcarbonyl)amino, or alkoxy; and R2 is alkyl or aryl), which comprises converting a compound of the general formula (I) or a salt thereof: into an acid halide corresponding thereto, reacting this acid halide with a malonic ester and a magnesium alkoxide, treating the obtained product with an acid, and reacting the resulting product with sulfur and a compound of the general formula: NCCH¿2COOR?2 or a salt thereof in the presence of a primary amine. The processes make it possible to mass-produce thienopyrimidine derivatives exhibiting GnRH antagonism in high yield at high efficiency on an industrial scale by simple means. |
| priorityDate | 2000-02-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.