http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1263783-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f70c1c4ba071d62460b17f9f396a1aa8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43522 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435 |
| filingDate | 2001-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_281bf190378da7254be89b7d9fbb05d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cae1128de9216ffcd48fa21617870d09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d875c189fcc09fa268e00afa38e57958 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_958e4df33b476c450d3cc664b0402378 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58c11dd15adacd9cb0ee5dd72d9ab69f |
| publicationDate | 2002-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1263783-A2 |
| titleOfInvention | Maurocalcine, analogues thereof and their therapeutical uses |
| abstract | Maurocalcine, a novel toxin isolated from the venom of the Tunisian chactidae scorpion Scorpio maurus palmatus, has the amino acid sequence GDCLPHLKLCKENKDCCSKKCKRRGTNIEKRCR (SEQ. ID. No. 1). It potently and reversibly modifies channel gating behaviour of type 1 ryanodine receptor (RyR1) by inducing prominent subconductance behavior. Maurocalcine and its bioactive structural analogues - preferably those containing the KKCKRR motif corresponding to part of the II-III loop of the alpha1S subunit of the voltage-dependent skeletal muscle calcium channel dihydropyridine receptor - appear to possess a therapeutic potential, notably as candidate immuno-suppressive drugs, and for the treatment of pathologies in humans that may involve a dysfunction of calcium channels. |
| priorityDate | 2000-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.