http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1261624-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2105b9682ef875ab2d232684e85f8260 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0821 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0825 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-097 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-16 |
| filingDate | 2001-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dda6ee442ef2824ddddc891b4c6bc310 |
| publicationDate | 2002-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1261624-A1 |
| titleOfInvention | Trh-like peptide derivatives as inhibitors of the trh-degrading ectoenzyme |
| abstract | Peptide derivatives useful as inhibitors of activity of thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE) are of formula Ia, wherein R1 is an optionally substituted 4-, 5- or 6-membered heterocyclic ring having one or more heteroatoms, in which at least one carbon of the ring is substituted with O or S; X1 is -CO- or -CS- or -CH¿2?CO- or CH(R?4¿) wherein R4 is H or optionally substituted alkyl or -COOH or -COOR11 wherein R11 is optionally substituted alkyl; X?2 and X3¿ (which may be the same or different) are -CO- or -CS-; Z is -CH¿2?- or -S- or -O- or -NH-; Q is O or S; R?2¿ is H or optionally substituted alkyl or an optionally substituted carbocyclic ring; R3 is H or optionally substituted alkyl or an optionally substituted mono- or polycyclic ring, optionally having one or more heteroatoms in the ring(s) and optionally being a fused ring; or R?2 and R3¿ together form an optionally substituted mono- or polycyclic ring optionally having one or more heteroatoms in the ring(s) and optionally being a fused ring; R?5 and R6¿ (which may be the same or different) are H, or lower alkyl; R?7 and R8¿ (which may be the same or different) are H, or optionally substituted lower alkyl; R?9 and R10¿ (which may be the same or different) are H, or optionally substituted alkyl or an optionally substituted carbocyclic ring; Y is -(CH¿2?)n- where n is 0, 1, 2 or 3 provided that when R?2 and R3¿ form part of the ring n is 0; and pharmaceutically acceptable salts thereof. |
| priorityDate | 2000-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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