| abstract |
An oligomer comprising at least two nucleomonomers and pharmaceuticallynacceptable salts thereof wherein at least one of said nucleomonomers comprises a basenof formula (1) or (2):n n wherein each X is independently O or S; R 2 is a group comprising at least one pi bond connected to the carbon atomnattached to the base; Pr is (H) 2 or a protecting group; n with the proviso that when at least one of said nucleomonomers of said oligomerncomprises deoxyuridine 5-substituted by vinyl, 1-butenyl, 1-pentenyl, 1-hexenyl, 1-heptenyl,n1-octenyl, 1-propynyl, 1-butynyl, 1-hexynyl, 1-heptynyl, or 1-octynyl, thennthe remainder of the nucleomonomers comprising said oligomer are not solelyncomprised of phosphodiester linked 2'-deoxyadenosine, 2'deoxyguanosine, 2'-deoxycytidine,nthymidine or a combination thereof; and wherein said oligomer includesnat least one unit having one of thirteen specific formulas. |