| abstract |
Pharmaceutical compositions exhibiting thrombopoietin receptor agonism, which contain as the active ingredientncompounds of the general formula (I): X 1 -Y 1 -Z 1 -W 1 prodrugs of the same, pharmaceutically acceptable salts of both, or solvates ofnthem wherein X 1 is optionally substituted aryl, optionally substituted heteroaryl, or the like; Y 1 is -NR A CO-(CH 2 ) 0-2 - (wherein R A nis hydrogen or the like) or the like; Z 1 is optionally substituted phenylene or the like; and W 1 is a group of the general formula (II):n(II) (wherein R 1 , R 2 , R 3 and R 4 are each independently hydrogen, optionally substituted lower alkyl, or the like; and the broken linenrepresents the presence or absence of a bond), or the like. |