| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ddb9f3656270bc5410be3679322fead |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-367
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C327-32 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-367
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C327-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-60 |
| filingDate |
2001-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d25ba8f5a3cc28f95825823a755fad05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dec23ab074ab91aca1380752870b6cac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_096964e35b77ec54e59ab38211499de7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5fa521858278fc2042d23c9dcd4c19a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c29b5055f758caa81388d952ffdf5c55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76c16123b3822661a07d1a127dd29a48 |
| publicationDate |
2002-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1251115-A1 |
| titleOfInvention |
Process for producing optically active carboxylic acid substituted in 2-position |
| abstract |
A nitrous acid salt is added at a temperature of 10 to 80 DEG C to an aqueous solution which contains an optically active 2-aminocarboxylic acid (4) and a protonic acid, the amount of the latter acid being 1 to 3 equivalents to the former, and which has a proton concentration of 0.5 to 2 mol/kg to conduct a reaction to thereby produce an optically active 2-hydroxycarboxylic acid (1). Thionyl chloride and a basic compound are caused to act on the compound (1) to chlorinate it and simultaneously invert the configuration in the 2-position. Thus, an optically active 2-chlorocarboxylic acid chloride (5) is induced. The compound (5) is hydrolyzed to induce an optically active 2-chlorocarboxylic acid (2). The compound (2) is reacted with a thioacetic acid salt to incorporate an acetylthio group thereinto and simultaneously invert the configuration in the 2-position to thereby produce an optically active 2-acetylthiocarboxylic acid (3). <CHEM> |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7473803-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1481960-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102276442-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102276442-A |
| priorityDate |
2000-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |