| abstract |
Disclosed are compounds of formula (I) wherein : L is (a) optionally substituted by replacement of one or more of the hydrogen atoms on the phenanthrene ring system by one or more groups other than hydrogen; A is CH2, SO2 or C=O; X is CO2H, PO3H2, PO2H2, PO2HR<5>, PO2HOR<5>, SO3H, SO2H, or tetrazole; and R<1>, R<2>, R<3>, R<4> and R<5> are independently selected from H, alkyl, alkenyl, alkynyl, aryl and aralkyl; or a pharmaceutically acceptable acid salt or base addition salt or an <i>in vivo</i> hydrolysable ester or amide thereof. Compounds of formula (I) are selective NMDA receptor modulating agents and, therefore, may be used to advantage <i>in vitro</i> in neuroassays and <i>in vivo</i> in the treatment of disorders of the CNS. |