| abstract |
The present invention provides a compound consistingnof a moiety and a group chemically bonded to said moiety,nwherein said moiety contains a compound having lownactivity following oral administration or its parentnscaffold and said group has the following general formulan(1):n nin whichn R 1 represents a hydrogen atom, etc., R 2 represents a C 1 -C 7 halogenoalkyl group, etc., m represents an integer of 2 to 14, and n represents an integer of 2 to 7, nor enantiomers of the compound, or hydrates ornpharmaceutically acceptable salts of the compound ornenantiomers thereof. The above compound is advantageousnin pharmaceutical use because the group of general formulan(1) allows compounds such as anti-estrogenic ones to showna significantly increased activity following oralnadministration when attached to the parent scaffolds ofnthe compounds. |