| abstract |
The present invention relates to a medicinal aerosol solutionnformulation product with improved chemical stability, comprising anpressurized metered dose inhaler (10), comprising an aerosol canistern(16) equipped with a metering valve (18) and containing a medicinalnaerosol solution formulation (12) containing an active ingredientnsubject to a degradation by means of peroxides, a hydrofluorocarbonnpropellant, a co-solvent and optionally a low-volatility component,nwherein part or all of the internal surfaces of said inhaler consists ofnstainless steel, anodized aluminum or are lined with an inert organicncoating, and wherein the canister has a rim with rounded edgesn(40,42,44,46) which avoids breaks in the rubbers used as valve gasketsn(30). |