http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1239775-A1

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filingDate 2000-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2002-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-1239775-A1
titleOfInvention Device for enhancing transdermal flux of sampled agents
abstract A transdermal agent sampling device is provided. The sampling device is comprised of a microblade array and a device for applying a partial vacuum. The microblade array comprises a sheet having a plurality of microblades for piercing the skin to a very shallow depth (i.e., 25 mum to 400 mum) to create microslits in the outermost stratum corneum layer of the skin. The partial vacuum applying device applies a partial vacuum in the range of about 0.1 to about 0.8 atm, and preferably about 0.3 to about 0.7 atm, for sampling a body analyte such as glucose in interstitial fluid. The partial vacuum is applied for a period of about 2 to about 30 seconds, and preferably about 5 to about 15 seconds. The interstial fluid is analyzed for body analyte (e.g., glucose) content or concentration.
priorityDate 1999-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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