http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1237846-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d648658dd620f548c24de39659a5e9e3 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-28 |
| filingDate | 2000-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9a8bfd602b19dd72571ac936c33f516 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2f8035b5fe8731bdc80854a5a86cf16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de336fa51586dd4882c7fa4489ec482b |
| publicationDate | 2002-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1237846-A1 |
| titleOfInvention | Preparation of 3-amino-3-cyclopropylpropanoate esters |
| abstract | Disclosed is a process for preparing substantially enantiomerically pure 3-amino-3-cyclopropylpropanoate esters, i.e., esters of 3-amino-3-cyclopropylpropanoic acid (3-cyclopropylalanine esters or 3-CPA esters) by a 5-step process wherein cyclopropanecarboxaldehyde (CPCA) is reacted with malonic acid and a source of ammonia to obtain 3-cyclopropylalanine (3-CPA); esterifying the 3-CPA; contacting the 3-CPA ester with a substantially enantiomerically pure acid selected from tartaric acid, dibenzoyltartaric acid and mandelic acid to obtain a diastereomeric salt of the 3-CPA ester and the acid; recrystallization of the salt to substantial diastereomeric purity; and neutralizing the salt to afford the substantially enantiomerically pure 3-CPA ester. |
| priorityDate | 1999-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 81.