| abstract |
An oxadiazole derivative of formula (I) and a non-toxicnsalt thereof,n nwherein R is hydrogen, alkyl, CycA, etc.; AA 1 is a single bond,namino acid residue, etc.; AA 2 is a single bond, amino acidnresidue, etc.; R 7 and R 8 are hydrogen, alkyl, etc.; R 9 is hydrogen,nalkyl, etc.; R 10 is hydrogen, alkyl, etc.). n The compound of formula (I) has an inhibitory activitynagainst cysteine protease and therefore it is useful as an agentnfor the prophylaxis and/or treatment of inflammatory diseases,ndiseases induced by apoptosis, diseases induced by disordersnof immune responses, autoimmune diseases, diseases induced byndecomposition of proteins which compose organism, shock,ncirculatory system disorders, blood coagulation systemndisorders, malignant tumors, acquired immune deficiencynsyndrome (AIDS) and AIDS-related complex (ARC), parasiticndiseases, nerve degeneration diseases, pulmonary disorders,nbone resorption diseases, endocrinesthenia, etc. |