| abstract |
A method of immuno-assay comprises immunologically measuring in a biological sample the amount of an isomerised or optically inverted non-collagen protein derived from cartilage or of one or more isomerised or optically inverted fragments from such a protein. The method may determine the amount of at least one *Asx or *Glx containing protein or protein fragment in said biological sample, wherein *Asx is alpha D Asp or Asn or is beta L or beta D Asp and *Glx is alpha D Glu or Gln or gamma L or gamma D Glu. The protein may be aggrecan, CLP, COMP, or CILP or said fragment is a fragment of aggrecan, CLP, COMP, or CILP. |