| abstract |
Compounds of formula (I) and physiologically acceptable salts and or metabolically labile derivatives thereof, wherein R1 represents a group selected from CXR2, CXOR3, CONHR4 or SO2R5; X is oxygen or sulphur; R8 represents a group selected from hydrogen, C1-6 straight or branched chain alkyl, C3-6 straight or branched chain alkenyl, optionally substituted phenyl or C1-4 alkyl substituted with a group selected from C1-4alkoxy, hydroxy, acyloxy, alkoxy carbonyl or aryloxycarbonyl, and R9 represents a group selected from formyl or cyano, processes for their preparation, pharmaceutical compositions containing then and their use in medicine. |