| abstract |
The present application provides a human gene over-expressingnanimal, which is a non-human animal carrying a human hematopoieticnprostaglandin D 2 synthase gene in its somatic cell chromosome andnexpressing a large amount of human prostaglandin D 2 synthase, wherein thenanimal is one obtained through ontogenesis of a totipotency cell of annon-human animal or offspring of the obtained animal, and the totipotencyncell is introduced with said synthase gene. The present application alsonprovides a method of using the transgenic animal for testing in vivo activity ofna candidate for anti-allergy medicines, sleep-controlling substances andncandidates for anti-obesity. |