| abstract |
Novel 2'-O-alkyl guanosine compounds and analogs thereof are provided. Processes fornthe preparation of 2'-O-alkyl guanosine and analogs thereof are also provided. Processesnfor preparing 2'-O-alkylated guanosine, uridine, cytidine, and 2,6-diaminopurine 3'-O-phosphoramiditesnare also provided. Methods for the use of oligonucleotides comprisingn2'-O-alkyl guanosine are also provided. |