| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03627f82d4edc6567f9627df6efdde5d |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-255
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-71
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-68 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-71
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-255
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-68 |
| filingDate |
1996-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee7c0f8c766b41dec96ed73606e81d03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c476dd11a28ee8b866004c5e12dfdf04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ab46cb8be551ad351a9ee70d35049ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6745f6950f9bbbb7f336b35242308d6a |
| publicationDate |
2002-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1223156-A1 |
| titleOfInvention |
Use of 4-substituted 2-butanones to prepare nabumetone |
| abstract |
The palladium-catalyzed coupling of aryl and vinyl halides with vinylicncompounds is disclosed. A preferred embodiment relating to the palladium catalyzed couplingnof 4-substituted and 6-substituted-2-methoxynaphthalene to form nabumetone is also disclosed.nThe beauty of this novel reaction is that methylvinylketone, normally employed by the artndirectly as-is for the preparation of nabumetone, is formed in situ . We have discovered anmechanism to take advantage of the in situ formation of methylvinylketone, thus avoiding thenuse of expensive, toxic, and unstable methyl vinyl ketone feed. This reaction may be employednfor a variety of pharmaceutically active and non-pharmaceutical compounds. |
| priorityDate |
1995-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |