| abstract |
An aromatic nitrogen-containing 6-membered cyclic compoundnof the formula (I):n nwherein Ring A is a substituted or unsubstituted nitrogen-containingnheterocyclic group; R 1 is a substituted or unsubstituted lower alkylngroup, -NH-Q-R 3 (R 3 is a substituted or unsubstituted nitrogenncontaining heterocyclic group, and Q is a lower alkylene group or ansingle bond), or -NH-R 4 (R 4 is a substituted or unsubstituted cycloalkylngroup); R 2 is a substituted or unsubstituted aryl group; one of Y and Znis =CH―, and the other is =N―, or a pharmaceutically acceptable saltnthereof, these compounds exhibiting excellent selective PDE V inhibitorynactivities, and hence, being useful in the prophylaxis or treatment ofnpenile erectile dysfunction, etc. |