| abstract |
The present invention relates to compounds of the formula I,n R 0 -Q-X-Q'-W-U-V-G-M nin which Q; X; Q', U, V, G and M have the meanings indicated in thenclaims; R 0 is aryl or heteroaryl; and W is selected from aryl,nheteroaryl, carbocyclic and heterocyclic groups. The compounds of thenformula I are valuable pharmacologically active compounds. They exhibitna strong antithrombotic effect and are suitable, for example, for thentherapy and prophylaxis of cardiovascular disorders like thromboembolicndiseases or restenoses. They are reversible inhibitors of the bloodnclotting enzymes factor Xa(FXa) and/or factor VIIa(FVIIa), and can inngeneral be applied in conditions in which an undesired activity ofnfactor Xa and/or factor VIIa is present or for the cure or prevention ofnwhich an inhibition of factor Xa and/or factor VIIa is intended. Theninvention furthermore relates to processes for the preparation ofncompounds of the formula I, their use, in particular as activeningredients in pharmaceuticals, and pharmaceutical preparations comprising them. |