| abstract |
The invention provides compounds and compositions of the formula: wherein, the subscript n is an integer of from 0 to 4; Ar is a member selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl, R<SUP>1 </SUP>is a member selected from the group consisting of substituted or unsubstituted (C<SUB>5</SUB>-C<SUB>15</SUB>)alkyl and (C<SUB>8</SUB>-C<SUB>14</SUB>)acyl group; R<SUP>2 </SUP>is a member selected from the group consisting of substituted or unsubstituted (C<SUB>1</SUB>-C<SUB>8</SUB>)alkyl; each R<SUP>3 </SUP>is independently a substituent Y is a member selected from the group consisting of substituted or unsubstituted (C<SUB>2</SUB>-C<SUB>8</SUB>)alkylene and substituted or unsubstituted (C<SUB>2</SUB>-C<SUB>8</SUB>)heteroalkylene; Z is -NR<SUP>4</SUP>R<SUP>5 </SUP> R<SUP>4 </SUP>and R<SUP>5 </SUP>are independently selected from the group consisting of hydrogen and (C<SUB>1</SUB>-C<SUB>8</SUB>)alkyl or taken together with the nitrogen atom to which each is attached to form a heterocyclyl or heteroaryl; These compounds and compositions bind to the CXCR3 chemokine receptor and are useful for treating diseases and conditions responsive to the modulation of CXCR3 activity, such as multiple sclerosis, rheumatoid arthritis, psoriasis, cancer, infectious disease, angiogenesis, and graft rejection. |