| abstract |
A controlled-release dosage form for a phamaceutically-active agentncomprises a core, in which the agent is dispersed, surrounded by andiffusion-limiting sleeve. The agent is released at a zero-order or approximatelynlinear rate because the release rate of the agent will be governed entirely bynerosion from exposed core surfaces; the surface area of which does not changensubstantially during the release process. Such a product may be made by coextrudingnthe core and sleeve material and slicing the extrudate. |