| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb8f3eba86915d967beefc175437273a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1721d75f5bf603447ec5a26b5c1c0be0 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-16 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate |
2000-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f632fd02b224b6a358e670643a69f150
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38889510f3584875cab02c5b3216ec47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6016e6291064f4d108160d1095e1788
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae23d093987237ea6e47a54701feed2d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_672a9a6b7e5f83b090a03b32ff7c4e88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73eb99db0035fa08cb2580b662bef662
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e28bc7aa8329fd02df1ab9f78c52cf3 |
| publicationDate |
2002-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-1212357-A1 |
| titleOfInvention |
Crystal structure of a deacetylase and inhibitors thereof |
| abstract |
The present invention provides three-dimensional structural information from the hyperthermophilic bacterium Aquifex aeolicus which is a histone deacetylase-like protein (HDLP). HDLP shares 35.2% amino acid sequence identity with human histone deacetylase (HDAC1). The present invention further provides three-dimensional structural information of HDLP bound by inhibitor molecules. The three-dimensional structural information of the present invention is useful to design, isolate and screen deacetylase inhibitor compounds capable of inhibiting HDLP, HDAC family members and HDLP-related molecules. The invention also relates to nucleic acids encoding a mutant HDLP which facilitates the determination of the three-dimensional structure of HDLP in the presence of a zinc atom. |
| priorityDate |
1999-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |