| abstract |
Benzoic acid derivatives of formula (I), which act as peroxisome proliferator activated receptor (PPAR) agonists, in particular states of insulin resistance including type 2 gamma receptors (PPAR), and so are useful therapeutically in the treatment of diabetes mellitus. In said formula Q, X, Y and Z are either -CR?a=, -CRb=CRc¿- or -N=; where R?a, Rb and Rc¿ are independently selected from hydrogen, halo or a bond, such that together with the nitrogen atom to which Y and Z are attached, they form a five or six-membered aromatic ring; R?1 and R3¿ are independently selected from C¿1-3?alkyl, halo, haloC1-3alkyl, C1-3alkoxy, or haloC1-3alkoxy; n and m are independently selected from 0, 1 or 2; A is an alkylene, alkenylene or alkynylene chain optionally interposed by a heteroatom; and R?2¿ is an optionally substituted aryl, optionally substituted heterocyclyl or optionally substituted cycloalkyl moiety. |