http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1208093-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3ddd5f458039b813e6ccbbaa3fc15666 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D227-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-185 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D227-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-092 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-185 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-62 |
| filingDate | 2000-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff4c8f885d4f4565773d92300523e738 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cdd0e2f69cecce32514746766f1b28f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e5e7bd98bad891243ea0a268d430800 |
| publicationDate | 2002-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1208093-A1 |
| titleOfInvention | Cinnamic acid nitrile method of production and use thereof |
| abstract | The invention relates to substituted cinnamic acid nitriles of the formula (I) wherein X = CN, COOR?4, CONR5R6¿, COaryl, COalkyl, aryl, heteroaryl, R1 = H, alkyl, arylalkyl, [4-(2-alkoxyphenyl)-1-piperazinyl]alkyl, R?2 and R3¿ = independent of each other H, hydroxy, alkoxy, benzyl, R4 = H, alkyl, [4-(2-alkoxyphenyl)-1-piperazinyl]alkyl, R5 = H, alkyl, alkoxyalkyl, alkoxy-oxoalkyl, diakylaminoalkyl, amino-oxoalkyl, aryl, arylalkyl, [4-(2-alkoxyphenyl)-1-piperazinyl]alkyl, morpholinoalkyl, furanyalkyl, thienylalkyl, R6 = H, alkyl, or NR5R6 together = cyclic amines such as pyrrolidine, morpholine, piperidine, subst. piperazine, whereby at least one of the radicals R?1, R4 or R5¿ is a [4-(2-alkoxyphenyl)-1-piperazinyl]alkyl-radical, in addition to the addition thereof with pharmacologically compatible acids. The compounds are active as prophylactic and therapeutic medicaments for the treatment of benign prostatahyperplasia. A method for the production of cinnamic acid nitrile is also disclosed; an appropriately substituted benzaldehyde is reacted with a substituted acetonitrile in a Knoevenagel-condensation reaction. |
| priorityDate | 1999-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 195.