abstract |
Combinations of an ACE inhibitor, annaldosterone receptor antagonist and a diuretic, i.e.,n"triple therapy" combinations, are described for use inntreatment of circulatory disorders. of particularninterest are triple therapies using captopril ornenalapril co-administered with a low-dose ofnspironolactone and furosemide. This triple therapy wouldnbe particularly useful to treat or prevent thenprogression of congestive heart failure while avoiding ornreducing aldosterone-antagonist-induced side effects suchnas hyperkalemia. |