| abstract |
The present invention is related to sulfonamide derivatives having a lipophilic moietynand which are substantially soluble under physiological conditions. Said compounds arennotably for use as pharmaceutically active compounds. The present invention also relatednto pharmaceutical formulations containing such sulfonamide derivatives. Said sulfonamidenderivatives are efficient modulators of the JNK pathway, they are in particularnefficient and selective inhibitors of JNK 2 and 3. The present invention is furthermorenrelated to novel sulfonamide derivatives as well as to methods of their preparation.n n The compounds of formula I according to the present invention being suitable pharmaceuticalnagents are those whereinn Ar 1 and Ar 2 are independently from each other substituted or unsubstituted aryl or heteroarylngroups, X is O or S, preferably O; R 1 is hydrogen or a C 1 -C 6 -alkyl group, or R 1 forms a substituted or unsubstituted 5-6-memberednsaturated or unsaturated ring with Ar 1 ; n is an integer from 0 to 5, preferably between 1-3 and most preferred 1; Y within formula I is an unsubstituted or a substituted 4-12-membered saturated cyclicnor bicyclic alkyl which is substituted with at least one ionisable moiety to which a lipophilicnchain is attached and which is containing at least one nitrogen atom, whereby onennitrogen atom within said ring is forming a bond with the sulfonyl group of formula Inthus providing a sulfonamide.ring is forming a bond with the sulfonyl group of formulanI thus providing a sulfonamide. |