abstract |
Disclosed are compounds of the Formula In n wherein:n R 1 is hydrogen, lower alkyl, or cycloalkyl; R 2 is hydrogen, lower alkyl, lower alkoxy, halogen, hydroxy, aryl, heteroaryl,narylalkyl, heteroarylalkyl, arylalkoxy, heteroarylalkoxy, cyano, carboxy,nalkoxycarbonyl, carbamoyl, sulfamoyl, nitro, trifluoromethyl, amino, ornmono- or dialkylamino; and R 3 and R 4 independently are hydrogen, lower alkoxy, aryl, heteroaryl, halogen,nhydroxy, cyano, carboxy, alkoxycarbonyl, carbamoyl, sulfamoyl, nitro,ntrifluoromethyl, amino, mono- or dialkylamino, or unsubstituted ornsubstituted lower alkyl or lower alkenyl; or R 3 and R 4 together form an unsubstituted or substituted carbocyclic group. n Also provided is a method of inhibiting the aggregation of amyloidnproteins using a compound of Formula I and a method of imaging amyloidndeposits. |