| abstract |
The present invention is related to benzsulfonamide derivatives of formula I notably fornuse as pharmaceutically active compounds, as well as to pharmaceutical formulationsncontaining such benzsulfonamide derivatives. Said benzsulfonamide derivatives are efficientnmodulators of the JNK pathway, they are in particular efficient and selective inhibitorsnof JNK 2 and 3. The present invention is furthermore related to novel benzsulfonamidenderivatives as well as to methods of their preparation.n n The compounds of formula I according to the present invention being suitable pharmaceuticalnagents are those whereinn Ar 1 is a substituted or unsubstituted aryl or heteroaryl group; Ar 2 is a substituted or unsubstituted phenyl group; X is O or S, preferably O; R 1 is hydrogen or a C 1 -C 6 -alkyl group, or R 1 forms a substituted or unsubstituted 5-6-memberednsaturated or unsaturated ring with Ar 1 ; n is an integer from 0 to 5, preferably between 1-3 and most preferred 1; Y within formula I is an unsubstituted or a substituted 4-12-membered saturated cyclicnor bicyclic alkyl containing at least one nitrogen atom, whereby one nitrogen atomnwithin said ring is forming a bond with the sulfonyl group of formula I thus providing anbenzsulfonamide. |