http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1189939-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cc4209078d025bee83bc1ad02a70fcf2 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4747 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2000-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb2bb6262ae47a6c65761a295773c04a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4e77995b27864972fbd016c1cec6682 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_849794144df1b7c134766dbce2ae57c0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4eb48d7ad2a4d0a9df3221dcd3cf9e82 |
| publicationDate | 2002-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1189939-A1 |
| titleOfInvention | Bh3 modified peptides |
| abstract | The present invention is directed to a peptide of formula (I), as defined herein, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising said peptide of formula (I), and the use thereof to restore apoptosis in human tumor cells. A compound of formula (I) of the present invention is R-A?1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-NHR1¿ or a pharmaceutically acceptable salt thereof wherein, R is (C¿1?-C5)acyl; A?1¿ is absent or an aliphatic amino acid; A2 is absent or is selected from the group consisting of Gly, Ala, Ser, Thr and Asn; A?3 and A4¿ are each absent or are each a coded amino acid; A5 is an aliphatic amino acid; A6 is Ala or a basic amino acid; A7 is selected from the group consisting of Ile, Leu, Val, Ser, Thr, Lys and Arg; A8 is an aliphatic amino acid; A9 is Gly; A?10 and A11¿ are each independently Asp or Glu; A12 is an aliphatic amino acid Ile, Leu, Met and Val; A13 is Asp, Glu or Asn; A?14 and A15¿ are each independently absent or selected from the group consisting of Ile, Leu, Val, Met, Ser, Thr, Asn, Lys and Arg; and R1 is (C¿1?-C5)alkyl. |
| priorityDate | 1999-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 193.