| abstract |
Novel acylhydrazine derivatives exhibiting anninhibitory activity against activated blood coagulationnfactor X, which are compounds of general formula (I)n nor salts thereof, wherein R is an optionallynsubstituted hydrocarbon group or an optionallynsubstituted heterocyclic group; R 1 and R 2 are eachnhydrogen or optionally substituted hydrocarbyl, ornalternatively R 1 and R 2 or the substituent of X 1 and R 2 nmay be united to form an optionally substituted ring; X 1 nand X 2 are each free valency, optionally substitutednalkylene, or optionally substituted imino; D is oxygennor sulfur; A is -N(R 3 )-Y- or -N=Y-, R 3 is hydrogen,noptionally substituted hydrocarbyl, or acyl; Y is annoptionally substituted chain hydrocarbon group or annoptionally substituted cyclic group; and Z is (1)noptionally substituted amino, (2) optionallynsubstituted imidoyl, or (3) an optionally substitutednnitrogenous heterocycle group. |