| abstract |
A compound of the formula:n nwherein R 1 is a hydrocarbon group, R 2 is a hydrocarbon groupnhaving 2 or more carbon atoms, where R 1 and R 2 may inncombination form, together with an adjacent nitrogen atom, anring optionally having a substituent or substituents, R 3 is anhydrocarbon group optionally having a substituent ornsubstituents or a heterocyclic group optionally having ansubstituent or substituents, R 4 is a hydrogen atom, anhydrocarbon group, a heterocyclic group and the like, E is andivalent chain hydrocarbon group and the like, G is CO or SO 2 ,nJ is a nitrogen atom, a methine group and the like, and Q and Rnare each a divalent chain C 1-3 hydrocarbon group and the like,nand a salt thereof show a superior CCR5 antagonistic activitynand are useful as agents for the prophylaxis or treatment ofnHIV infection of human peripheral blood mononuclear cells,nparticularly AIDS. |