http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1178786-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9f0cc96d00cd8246992edcd22816725d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5169 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1075 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 |
| filingDate | 2000-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cfa6c282fb5aff2da20bc608881c0731 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf32764b3525d3599e34921c530aa4ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edafbc24673494e8ded1ae6ba8b8b90e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d0214d261b62e6e031a0c717915775e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c1e291a6a299b2a758a2df1ec81c175 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72c65eef6103f047af8b00faad57e1e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2cc16cab1ebca785667fd03c6307bc0a |
| publicationDate | 2002-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1178786-A1 |
| titleOfInvention | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
| abstract | In accordance with the present invention, there are provided compositions and methods useful for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug paclitaxel) in which the pharmacologically active agent is delivered in the form of suspended particles coated with protein (which acts as a stabilizing agent). In particular, protein and pharmacologically active agent in a biocompatible dispersing medium are subjected to high shear, in the absence of any conventional surfactants, and also in the absence of any polymeric core material for the particles. The procedure yields particles with a diameter of less than about 1 micron. The use of specific composition and preparation conditions (e.g., addition of a polar solvent to the organic phase), and careful election of the proper organic phase and phase fraction, enables the reproducible production of unusually small nanoparticles of less than 200 nm diameter, which can be sterile-filtered. The particulate system produced according to the invention can be converted into a redispersible dry powder comprising nanoparticles of water-insoluble drug coated with a protein, and free protein to which molecules of the pharmacological agent are bound. This results in a unique delivery system, in which part of the pharmacologically active agent is readily bioavailable (in the form of molecules bound to the protein), and part of the agent is present within particles without any polymeric matrix therein. |
| priorityDate | 1999-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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