| abstract |
The present invention relates to methods of sealing a tissue injection site into which a therapeutic agent has been injected, which allow for increased efficiency or better absorption of the agent. Likewise, the invention relates to methods of delivering a therapeutic agent into a tissue, comprising injecting a therapeutic agent into a tissue and then sealing the injection site, or introducing an injection device into the tissue. for a period sufficient for sealing not to be necessary, to avoid leakage of the therapeutic agent. In one embodiment, radio frequency cauterization is used to seal the injection site during removal of the needle from the tissue. In other embodiments, the injection site is sealed by resistance heating, by laser heating, or by plugging the site using a solid plug, or by coagulating material at the site. |