| abstract |
A new oral pharmaceutical dosage form comprising a core material that contains a protonnpump inhibitor, one or more alkaline reacting compounds and optionally pharmaceuticalnexcipients having a water soluble separating layer and an enteric coating layer. The corenmaterial as such is alkaline reacting and the separating layer between the alkaline reactingncore material and the enteric coating layer is formed in situ as a water soluble salt betweennthe alkaline reacting compound(s) and the enteric coating polymer. The invention alsondescribes a new efficient process for the manufacture of such a dosage form comprisingntwo functionally different layers in one manufacturing step, and its use in medicine. |