http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1171428-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_193a1eb20f5273c8af152507e588adfa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5513 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 |
| filingDate | 2000-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72f4e4d58d4e154632bbc078e9a3f5c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bad9502fdf4a159816edd5b1ce2a0db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5839d18882a4d00eccbc442d14e36354 |
| publicationDate | 2009-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1171428-B1 |
| titleOfInvention | Fab i inhibitors |
| abstract | Compounds of formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment of bacterial infections: wherein R1 is H, C¿1-6?alkyl or Ar-C0-6alkyl; R?2¿ is H, C¿1-6?alkyl, Ar-C0-6alkyl, HO-(CH2)n- or R'OC(O)-(CH2)n-; R?3¿ is A-C¿0-4?alkyl, A-C2-4alkenyl, A-C2-4alkynyl, A-C3-4oxoalkenyl, A-C3-4oxoalkynyl, A-C1-4aminoalkyl, A-C3-4aminoalkenyl, A-C3-4aminoalkynyl, optionally substituted by any accessible combination of one or more of R?10 or R7; R4¿ is (a), (b), (c), or (d); R5 is H, C¿1-6?alkyl, Ar-C0-6alkyl or C3-6cycloalkyl-C0-6alkyl; A is H, C3-6cycloalkyl, Het or Ar; R?7 is-COR8¿, -COCR'¿2R?9, -C(S)R8, -S(O)¿k?OR', -S(O)kNR'R'', -PO(OR'),-PO(OR')2, -B(OR')2, -NO2, or tetrazolyl; R?8¿ is -OR', -NR'R'', -NR'SO2R', or -NR'OR', -OCR'¿2?CO(O)R'; R?9¿ is -OR', -CN, -S(O)¿r?R', -S(O)kNR'2, -C(O)R', C(O)NR'2, or -CO2R'; R?10¿ is H, halo, -OR11, -CN, -NR'R11, -NO2, -CF3, CF3S(O)r-, -CO2R', -CONR'2, A-C0-6alkyl-, A-C1-6oxoalkyl-, A-C2-6alkenyl-, A-C2-6alkynyl-, A-C0-6alkyloxy-, A-C0-6alkylamino- or A-C0-6alkyl-S(O)r-; R11 is R', -C(O)R', -C(O)NR'¿2?, -C(O)OR', -S(O)kR', or -S(O)kNR'2; R' is H, C1-6alkyl, Ar-C0-6alkyl or C3-6cycloalkyl-C0-6alkyl; R'' is R', -C(O)R' or -C(O)OR'; R''' is H, C1-6alkyl, Ar-C0-6alkyl, HO-(CH2)2-, R'C(O)-, (R')2NC(O)CH2- or R'S(O)2-; X is H, C1-4alkyl, OR', SR', C1-4alkylsulfonyl, C1-4alkylsulfoxyl, -CN, N(R')2, CH2N(R')2,-NO2,-CF3, -CO2R', -CON(R')2, -COR', -NR'C(O)R', F, C1, Br, I, or CF3S(O)r-; k is 1 or 2; m is 1, 2 or 3; n is 1 to 6; and r is 0, 1 or 2; or a pharmaceutically acceptable salt thereof. |
| priorityDate | 1999-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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