| abstract |
Multiple novel reaction schemes, novel process steps and intermediatesnare provided for the synthesis of epoxymexrenone and other compounds ofnformula (I), wherein: -A-A- represents the group -CHR 4 -CHR 5 -nor CR 4 -CR 5 -; R 3 , R 4 and R 5 nare independently selected from the group consisting of hydrogen, halo,nhydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl,nhydroxycarbonyl, cyano, aryloxy; R 1 represents an alpha-orientednlower alkoxycarbonyl or hydroxyalkyl radical, -B-B- represents thengroup -CHR 6 -CHR 7 - or an alpha- or beta- orientedngroup of formula (III), where R 6 and R 7 are independentlynselected from the group consisting of hydrogen, halo, lower alkoxy, acyl,nhydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl,nacyloxyalkyl, cyano, aryloxy, and R 8 and R 9 arenindependently selected from the group consisting of hydrogen, halo,nlower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl,nalkoxycarbonyl, acyloxyalkyl, cyano, aryloxy, or R 8 andnR 9 together comprise a carbocyclic or heterocyclic ringnstructure, or R 8 or R 9 together with R 6 ornR 7 comprise a carbocyclic or heterocyclic ring structure fusednto the pentacyclic D ring. |