abstract |
The present invention provides an agent forntreatment of arthritic diseases such as rheumatoidnarthritis that has for its active ingredient a complex ofnhyaluronic acid and zinc. This complex synergisticallyninhibits proliferation of synovial cells and suppressesnmatrix metalloproteinase MMP-9, which is produced bynsynovial cells, as compared with its constituents,nhyaluronic acid and zinc, alone. |