Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6edb5285b39ab61950d1341a0eb9045f |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-4858 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-485 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1075 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-48 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 |
filingDate |
2000-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2216e72e85e68258776c582eb054a790 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ff93fd34c27f8e13bd92d075191bfab |
publicationDate |
2002-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-1165048-A1 |
titleOfInvention |
Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
abstract |
The present invention is directed to a pharmaceutical composition including a hydrophobic therapeutic agent having at least one ionizable functional group, and a carrier. The carrier includes an ionizing agent capable of ionizing the functional group, a surfactant, and optionally solubilizers, triglycerides, and neutralizing agents. The invention further relates to a method of preparing such compositions by providing a composition of an ionizable hydrophobic therapeutic agent, an ionizing agent, and a surfactant, and neutralizing a portion of the ionizing agent with a neutralizing agent. The compositions of the invention are particularly suitable for use in oral dosage forms. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8075874-B2 |
priorityDate |
1999-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |