| abstract |
Compounds which are useful in the efficient synthesis of 2-amino-4-oxobicyclo[3.1.0]hexane-2,6-dicarboxylic acid. The compounds are 2-oxobicyclo[3.1.0]hexane-6-carboxylic acid derivatives represented by formula (1) [wherein R1 represents hydrogen, C¿1-6? alkyl, C3-6 cycloalkyl, C1-6 alkyl substituted by C3-6 cycloalkyl, aryl, C1-6 alkyl substituted by aryl, C1-6 alkyl substituted by C1-6 alkoxy, C1-6 hydroxyalkyl, C1-6 alkyl substituted by C1-6 alkylthio, C1-6 mercaptoalkyl, tetrahydrofuranyl, or tetrahydropyranyl; R?2 and R3¿ are the same or different and each represents C¿1-6? alkyl, C3-6 cycloalkyl, C1-6 alkyl substituted by C3-6 cycloalkyl, aryl, or C1-6 alkyl substituted by aryl, or R?2 and R3¿ in combination represent -(CH¿2?)n- (n is 2 or 3); and Y?1 and Y2¿ are the same or different and each represents sulfur, oxygen, or nitrogen]. |