| abstract |
The present invention relates to the fields of biology and pharmacology. Thisninvention relates, generally, to methods and compositions for modulating oxLDLnactivity or transport. The present invention resides more specifically in methods fornscreening compounds that modulate oxLDL activity, more particularly oxLDLncellular uptake. The present invention more particularly describes novel methodsnof selecting or identifying compounds that can modulate oxLDL cellular uptake bynCD36 polypeptides in various cells, such as macrophages. The invention alsonrelates to the use of such compounds, in particular for research, development,nimprovement, diagnosis, therapeutic or prophylactic treatment of variousnpathological conditions. The invention also relates to the products or compositions,nsuch as CD36 variants, recombinant cells, vectors, kits, and the like, which can benused for implementing the above methods or for therapeutic purposes. |