http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1161453-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bfe5d59fd6b14c02afc38a0af2583c78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e0354d8cef23ac257594f21c83e1beeb |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-715 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate | 2000-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_139fc4b79aa0faa8679de7fce107cf07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f0bfd6c234ca5ebd919cedb18c13fb6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f034eec651e072e176eabe1a8affc48c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a168326a129028787063258cd49d980 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51293fc720a237ccc336d8193fa01478 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fbcf9ed1d40a760d10ffc25e03b2ef4 |
| publicationDate | 2001-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1161453-A1 |
| titleOfInvention | Cytokine-binding domain |
| abstract | The present invention provides a cytokine-binding domain or portion thereof which binds to at least one cytokine and is capable of transducing a cytokine signal through a single cytokine receptor, said domain comprising a portion of the B'-C' loop of domain 4 of a βc chain or analogous structure of a cytokine receptor. In another aspect of the invention there is provided a method of identifying a compound having cytokine agonist or antagonist activity, said method including subjecting a potential cytokine agonist and/or cytokine antagonist compound to a cytokine binding domain or portion thereof wherein said domain binds to at least one cytokine and is capable of transducing a cytokine signal through a single cytokine rectpor, said domain comprising a portion of the B'-C'loop of domain 4 of a βc chain or analogous structure of the cytokine recetoptor; and determining the presence of an agonist or antagonist response of the compound on the activity of a cytokine. In a preferred aspect there is provided a method of identitying a GM-CSF, IL-3 and IL-5 agonist or antagonist, said method including: subjecting a potential agonist or antagonist to a GM-CSF, IL-3 and IL-5 binding domain or portion thereof wherein said domain binds to at least one of the cytokines and is capable of transducing a cytokine signal through a single cytokine receptor, said domain comprising a portion of the B'-C' loop of domain 4 of a βc chain or analogous structure of the cytokine receptor; and determing the presence of an agonist or antagonist response from the compound on the activity of GM-CSF, IL-3 and IL-5. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11692039-B2 |
| priorityDate | 1999-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 323.