http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1159448-B1
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_589b4e7af26cc1f1fd30dee3d5cb9ced |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-77 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-811 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2337-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-974 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2337-22 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-86 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37 |
filingDate | 2000-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2004-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65db41dc784dffdfbdb4ca8c9389c8fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcf91d75c7a8dcc0685cb0d1f2251961 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef7d6f1f6f3a2685ea5e8ed54c7709cd |
publicationDate | 2004-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | EP-1159448-B1 |
titleOfInvention | Determination of biologically active forms of proteolytic enzymes |
abstract | A process is provided for the assessment of an active proteolytic enzyme in a blood or another biological fluid sample possibly comprising a complex of said proteolytic enzyme and alpha 2-macroglobulin, wherein said sample is contacted with a substrate comprising a molecule of sufficient size coupled to a signal-substrate, said signal-substrate comprising a detectable leaving group, wherein said substrate is hydrolysed by said proteolytic enzyme but not by said complex. The proteolytic enzyme is preferably selected from the group consisting of thrombin, activated clotting factor, activated fibrinolytic factor, and activated component of the complement system. Of these, thrombin is most preferred. The molecules of sufficient size are preferably water soluble and selected from the group consisting of inert protein, preferably ovalbumin, polysaccharide, and synthetic polymer. The size of these molecules is such that they will not fit into the cavity of the alpha 2M molecules. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7691641-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102006035899-A1 |
priorityDate | 1999-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.