| abstract |
Novel S-nitrosothiols derivatives of penicillaminenor glutathione, which correspond to following generalnformula(I)n nin which:n A and B are phenyl groups or together form the restn-CH 2 -Q-CH 2 - constituting a ring of six units in whichnQ represents an atom of oxygen, of sulfur, or angroup N-R 3 , in which R 3 is hydrogen or an alkyl groupnC 1 -C 4 ; R 1 is an acyl rest, which may be an aliphatic acylngroup C 1 -C 5 or a rest of glutamic acid bound via itsnnon amino acid carboxyl; R 2 is a hydroxyl group or a glycine rest bound via anpeptide bond; nwith the proviso that if R 1 is an aliphatic acyl restnthen R 2 is a hydroxyl group, and if R 1 is a rest of glutamicnacid then R 2 is a glycine rest. n The novel compounds have vasodilating activitynarid inhibit the aggregation of the platelets, which makenthem useful for the treatment of dysfunctions of the circulatorynsystem, specially at cardiovascular level. |