abstract |
A novel polypeptide for producing tert-butyln(3R,5S)-6-chloro-3,5-dihydroxyhexanoate, a gene encodingnthe polypeptide, and a method of using the polypeptide, arenprovided. The polypeptide has an enzyme activity tonasymmetrically reduce tert-butyl (S)-6-chloro-5-hydroxy-3-oxohexanoatento tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate.nThe polypeptide comprises thenamino acid sequence represented by SEQ ID NO. 1 in thenSequence Listing, or the amino acid sequence having at leastnone amino acid substitution, insertion, deletion, ornaddition thereof. |